Qamar then made her acting debut with a leading actress in the acclaimed biographical drama Manto (2015). Directed by Sarmad Khoosat, the film was made on a big budget and performed poorly at the box office with a lifetime collection of Rs 5.05 million, however it was critically praised and Qamar's portrayal of the singer Noor Jehan was well received by the critics, and earned her a nomination at the ARY Films Awards for Best Supporting Actress. The film was later adapted into a television series with the same cast in 2017, titled as Main Manto, and was aired on Geo TV.
In 2018, Qamar appeared in three short films. She first paired with Ahsan Khan in Siraj-ul-Haque directorial Moomal Rano. The film was made as part of the Zeal For Unity initiative to bridge cultural barriers between India and Pakistan. It was critically praised and was nominated for Best film at the 2018 European festival. It was also released by digital platform Zee5. She then appeared in Fahim Burney's Dil Diyan Gallan, opposite Zahid Ahmed where she played the character of Raniya and Iss Dil Ki Essi Ki Tessi. in 2019, Qamar worked in crime drama Cheekh, opposite Bilal Abbas khan, she played a headstrong girl who fights for justice. It is considered both critical and commercial blockbuster. Qamar next collaborated with Sarmad Khoosat for film Kamli, and Saqib Khan's debut film, titled Ghabrana Nahi Hai. 2b1af7f3a8